Advancing Understanding of the Intracellular Complement System to Uncover a New Generation of Complement Based Therapeutic Targets
Time: 8:00 am
day: Pre-Conference Workshop Day
Details:
Join this workshop to enrich your knowledge of the approaches being used to deepen the mechanistic understanding of the intracellular complement system to uncover future therapeutic targets related to immunometabolism, the mitochondria and aging.
- Understanding the emerging insights into the complement system’s activity inside cells, beyond it’s traditional in blood serum-based role
- Discussing the subcellular locations of complement components with a heavy focus on the complosome effect on mitochondrial function along with the triggers and mechanisms driving the activation in these organelles
- Delving into the novel functions of the intracellular complosome such as cellular metabolism, genetic regulation, and the cell death cycle
- Highlighting the role of intracellular C3 in basic cell functions
- Emphasizing the cellular and molecular consequences of a dysregulated complosome within renal cells
- Exploring the unique contributions of intracellular complement to kidney disease pathogenesis, offering insights beyond classic extracellular complement pathways
- Addressing the exciting potential of the complosome as a new therapeutic target in age-related diseases
