Complement Inhibitor for the Treatment of Age-related Macular Degeneration: Target, Location of Delivery & Timing?

Time: 12:00 pm
day: Track A - Day 1 AM


  • Discover how the eye generates its own complement microenvironment, which is composed of RPE/choroidderived proteins and those delivered by the liver (circulation), and set up in part by differential permeability of Bruch’s Membrane to complement proteins
  • Complement activation appears to occur outside of the Blood Retina Barrier (basal side of RPE, BrM and CC)
  • As the goal is to identify a treatment for dry AMD that can be used early in disease, to prevent conversion from early to intermediate AMD (i.e., in the presence of a presumably intact BRB), how do we deliver the therapeutics accordingly?