Complement-Mediated Synapse Loss: A Viable Therapeutic Target in Multiple Sclerosis

Time: 12:00 pm
day: Track A - Day 1 AM


  • Synapse loss can occur early and as an independent pathology in multiple sclerosis (MS)
  • Synapse loss occurs as a consequence of complement C3 deposition at synapses and microglial synapse engulfment
  • Targeting C3 at synapses is a promising therapeutic target to preserve synapse structure and circuit function in MS

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