Discovering Granzyme K as a Potential 4th Complement Pathway
4:00 pm - Tuesday 2nd December 2025
- Granzyme K as an activator of the complement cascade through the cleavage of C2 and C4 proteins
- Initiating the full complement pathway, generating inflammatory molecules like C3a, C5a, opsonins, and the membrane attack complex
- Highlighting GZMK as a previously unrecognized and important contributor to tissue inflammation across various diseases, suggesting its potential as a novel therapeutic target