Therapeutic Targeting C5AR1 to Diagnosing & Preventing Early Rheumatoid Arthritis as a New Pathway to Precision Medicine

Time: 11:30 am
day: Track A - Day 1 AM


  • Recently RNAi therapeutic using siRNAs are almost replacing antibody therapeutics
  • CR5AR1 gene is expressed high, correlated with disease activity score 28 and a valid therapeutic target in Early Rheumatoid Arthritis
  • Highlighting how single targeting of C5-C5AR1 axis is not sufficient but double targeting of C5 and C5AR1 expression with a new conjugate of anti-C5AR1-C5siRNA is effective in reducing arthritis