Borislav Dejanovic

Company: Broad Institute

Job title: Associate Director


Neuronal Pentraxin Nptx2 Regulates Complement Activity & Restrains Microglia-mediated Synapse Loss in Neurodegeneration 2:00 pm

Complement C1q-dependent synapse elimination by glial cells in Alzheimer’s disease (AD) mouse models. Nptx2 binds C1q and restrains complement activity and synapse loss in neurodegeneration. Nptx2 concentration is decreased in CSF from AD and frontotemporal dementia patients, which correlates with elevated levels of C1q and activated C3Read more

day: Conference Day Two

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