Brahm Segal
Chair, Internal Medicine Moffitt Cancer Center
Dr. Segal is Chair of Internal Medicine, Chief of Infectious Diseases, Professor of Oncology and Member of the Department of Immunology at Roswell Park Comprehensive Cancer Center, a National Cancer Institute-designated comprehensive cancer center in Buffalo New York. He also holds an appointment as Professor of Medicine at the University at Buffalo’s Jacobs School of Medicine & Biomedical Sciences. His research is focused on innate immune responses to infection, injury, and the tumor microenvironment. Dr. Segal earned his MD from Albert Einstein College of Medicine.
Seminars
Whilst complement dysregulation is observed across a broad range of diseases, it remains unclear where complement therapeutics can deliver maximum benefit to patients whilst maintaining healthy immune function.
This workshop will cover:
- Evaluating which indications offer the greatest opportunity for complement intervention and determining where complement biology is most likely to translate into meaningful patient benefit
- Debating the role of complement therapies in acute versus chronic disease settings and identifying how dosing strategies and endpoints may differ between the two
- Exploring the potential for complement therapeutics beyond orphan diseases, including how to position complement modulation within complex, multifactorial conditions where complement is not the primary disease driver, as well as the potential of complement in oncology
- Assessing when complement intervention should occur within the patient journey, including optimal treatment windows, sustainable dosing regimens and approaches to maximizing long-term therapeutic impact
- Discussing how emerging biology and novel mechanisms are expanding the therapeutic potential of complement beyond nephrology
- Exploring solutions to delivery, target engagement and sample collection challenges in difficult-to-access tissues
- Identifying the key factors for success in new indications, including target selection, patient stratification and translational validation
