Mahmud Hossain
Senior Scientist Sanofi
Mahmud Hossain, PhD, has extensive research experience on mass spectrometry-based proteomics in academia (Cornell University, New York with Professor Fred W. McLafferty), National Laboratory (Pacific Northwest National Laboratory, Washington with Dr. Richard D. Smith) and pharmaceutical industries (Merck Research Laboratories, and Sanofi, Massachusetts). He is a member of the American Society for Mass Spectrometry and co-authored several research papers in peer-reviewed journals and book chapters, and in numerous conference proceedings. His current research at Sanofi Genzyme includes drug discovery and development using shotgun/targeted proteomics and bioanalytics. He received his PhD in Bioanalytical Chemistry from University of Cincinnati, Ohio, under the guidance of Professor Patrick A. Limbach.
Seminars
As the complement field expands beyond established targets, the challenge is identifying the mechanisms most likely to drive meaningful clinical benefit and developing robust approaches to demonstrate target engagement, differentiate therapeutic strategies and inform clinical development.
This workshop will cover:
- Evaluating emerging targets beyond C3 and C5, including upstream regulators, alternative pathway components, membrane attack complex targets and intracellular complement
- Elucidating pathological mechanisms to guide target selection and maximize therapeutic efficacy while preserving immune function
- Applying proteomics, biomarkers and functional assays to quantify complement activity, identify novel disease-driving mechanisms and de-risk target selection
- Addressing challenges in measuring target engagement, including sample acquisition, low-abundance proteins, pathway redundancy and the need for clinically meaningful biomarkers that accurately reflect biological activity
- Addressing challenges in sample collection to measure target engagement across a complex complement cascade
