Early Complement-Directed Therapeutic Reprogramming of Ferroptosis- Mitochondrial & Inflammasome Signaling to Prevent Secondary Brain Injury Traumatic Brain Injury & Hemorrhagic Shock

• Elucidating the mechanistic role of early complement activation in driving ferroptosis, mitochondrial dysfunction, and inflammasome signalling that contribute to secondary brain injury following traumatic brain injury and hemorrhagic shock
• Presenting preclinical evidence that early complement-directed interventions can therapeutically reprogram interconnected cell death and inflammatory pathways, preserve mitochondrial function and cellular bioenergetics, and mitigate progressive neurological damage after trauma
• Highlighting the translational potential of complement-targeted therapies as a novel precision medicine approach to preventing secondary brain injury and improving outcomes in patients with traumatic brain injury and hemorrhagic shock

NEW SPEAKING ORGANIZATION

Speakers:

Yansong Li

Principal Investigator

The Geneva Foundation