Michael Holers
Professor UCDHSC
speaker bio TEST
Seminars
Wednesday 3rd December 2025
Panel Discussion: Uncovering the Latest Technology in Preclinical Modelling Through the Promise of Humanized Complement Models in Drug Development
10:00 am
- Evaluating the utility of humanized complement models for testing complement inhibitors
- Delving into their advantages for human targeted agents
- Addressing key challenges such as incomplete humanization, low human protein expression and functional assay development
- Understanding how humanized complement models can be used to inform complement inhibitor dose prediction
Tuesday 2nd December 2025
Chair’s Opening Remarks
8:50 am
Wednesday 3rd December 2025
Panel Discussion: Uncovering the Latest Technology in Preclinical Modelling Through the Promise of Humanized Complement Models in Drug Development
9:30 am
- Evaluating the utility of humanized complement models for testing complement inhibitors
- Delving into their advantages for human targeted agents
- Addressing key challenges such as incomplete humanization, low human protein expression and functional assay development
- Understanding how humanized complement models can be used to inform complement inhibitor dose prediction
Tuesday 2nd December 2025
New Frontiers in Complement Imaging for Accurate Assessment of Activated Proteins within the Cascade
12:00 pm
- Identifying and validating immune-related blood-based biomarkers to serve as reliable read-outs for complement mediated diseases
- Delving into the complexities of discovering, developing, and validating biomarkers that accurately reflect the efficacy of complement-targeting drugs
- Focussing on generalized markers of complement activation an inflammation the retain relevancy across various conditions, moving beyond organ-specific structural biomarkers
Tuesday 2nd December 2025
Chair’s Opening Remarks
8:50 am
Tuesday 2nd December 2025
Chair’s Closing Remarks
5:00 pm
